Rinologichesky drug combination of alpha-sympathomimetic agent and the vitamin, for topical application to the nasal mucosa.Xylometazoline hydrochloride – imidazole derivative is alpha where to buy testosterone enanthate agonists, constricts blood vessels of the mucous membrane of the nasal cavity, eliminating edema and hyperemia of the mucous membrane.
Facilitates nasal breathing in rhinitis.
The drug usually occurs within 5-10 minutes after application and lasts for several hours. Dexpanthenol – . vitamin B complex – a derivative of pantothenic acid, Dexpanthenol is converted in the body into pantothenic acid, which is an integral part of coenzyme A and participates in the process of acetylation, carbohydrate and fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins;stimulates the regeneration of the skin, mucous membranes, normalizes cell metabolism, mitosis accelerates and increases the strength of collagen fibers. Provides regenerating, antiinflammatory and weak metabolic effect. In the experiment on animals (rats with deficiency dexpanthenol) was found effective impact dexpanthenol trophism of the skin. When applied topically dexpanthenol / panthenol able to meet increased demand for pantothenic acid is damaged skin or mucous membranes.
Xylometazoline hydrochloride when applied topically practically not absorbed, the plasma concentrations are so small that they can not be determined by modern analytical methods. Dekspanenol when applied topically quickly absorbed by the skin and is transformed into pantothenic acid bound to plasma proteins (mainly beta-globulin and albumin) . Its concentration in the blood – 0.5-1 mg / l in the blood serum – 100 g / l. Pantothenic acid is not subject to metabolism in the body (except for the inclusion in the Co-A), the output unchanged.
Acute allergic rhinitis, vasomotor rhinitis, acute respiratory disease with symptoms of rhinitis, sinusitis, hay fever; otitis media (to reduce swelling of the mucous membrane of the nasopharynx).
Preparing the patient for diagnostic procedures in the nasal passages and restoration of the nasal breathing after surgery in the nasal cavity.
Hypersensitivity to the drug, hypertension, tachycardia, marked atherosclerosis, glaucoma, atrophic rhinitis, surgical intervention on meninges (history).
The dry inflammation of the nasal mucosa (rhinitis sicca).
Children under the age of 6 years.
Only after careful evaluation of the benefit / risk of the drug can be used:
- patients taking where to buy testosterone enanthate monoamine oxidase inhibitors (MAOIs) or other drugs that increase blood pressure;
- patients with pheochromocytoma;
- patients with metabolic disorders (eg, hyperthyroidism, diabetes).
Pregnancy and lactation
Given that no evidence of reproductive toxicity of the drug during pregnancy and lactation is not recommended its use.
Dosing and Administration
For adults and children older than 6 years.
When using the bottle with pump dispenser packaged separately.
Remove the pump-action dispensing device from its packaging. Uncorked the vial is screwed on the bottle neck of the dispensing device, remove the protective cap. The vial is ready to use.
Prior to starting the spray several times to click on a pump dispensing device until a uniform spray.
When using the pump action bottle with integrated dosing Unit Removing the protective cap with a built-in pump-action dispensing device. The vial is ready to use.
Prior to starting the spray several times to press the built-in pump-action dispensing device until a uniform spray.
In the application of spray bottle must be held upright.
During the injection should be easy to inhale nose. One injection in each nostril 3-4 times a day.
Duration of treatment 3-5 days.
. Respiratory, thoracic and mediastinalnye disorders
Very rare: temporary mild irritation (burning or dryness of the nasal mucosa), especially in patients with hypersensitivity.
Very rarely or in individual messages: increased swelling of the mucous membrane of the nasal cavity.
Frequent and / or long-term use or by using large doses of Xylometazoline hydrochloride may receive burning and paresthesia of the nasal mucosa, the development of reactive edema with rhinitis medicamentosa. This effect can occur within 5 days from the start of treatment and during long-term use of lead to permanent damage mucosa to form scabs (rhinitis sicca).
. Violation of the nervous system
Rare or very rare: headache, vomiting, insomnia or fatigue, blurred vision; depression (with prolonged use at high doses).
Violations of the cardiovascular system:
Rare: palpitations, tachycardia, increased blood pressure.
Very rare: allergic reactions may occur.
In cases of overdose or accidental oral administration may experience the following symptoms: mydriasis, nausea, vomiting, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmias, circulatory collapse, cardiac arrest, hypertension, pulmonary edema, respiratory failure function, mental disorders.
Patients may also appear from the symptoms of CNS depression accompanied by drowsiness, decrease in body temperature, bradycardia, hypotension, shock type, cessation of breathing and coma.
The use of activated charcoal, gastric lavage, oxygen ventilation. For lowering blood pressure is prescribed 5 mg phentolamine in saline, by slow intravenous injection or orally 100 mg of phentolamine.Vasoconstrictor drugs are contraindicated. If necessary, apply anti-pyretic where to buy testosterone enanthate and anti-convulsants.
Interaction with other drugs
Concomitant use of monoamine oxidase inhibitors, tricyclic or tranylcypromine type antioxidants may lead to increased blood pressure due to the impact of these drugs on the cardiovascular system.
Before use, clean the nasal passages. Do not use more than 7 days.
Effects on ability to drive and use machines
With prolonged use or when used in high doses can not be excluded systemic drug reactions, including effects on the cardiovascular system and CNS. In such cases, the ability to drive and operate machinery may be impaired.
Nasal spray dosage 0.1 mg + 5 mg / dose. The bottle with pump action dispensing device packaged separately. In 10 mL (at least 100 doses) in amber glass vial, sealed with a polypropylene screw cap.Pomp dispensing device with a protective cap made of polypropylene packaged in individual packaging. One vial and one pump-action dispensing device together with instructions for use placed in a pile of cardboard. The bottle with integrated pump-action dispensing device. In 10 mL (at least 100 doses) in a vial amber glass with integrated pump-action dispensing device and a protective cap made of polypropylene. 1 bottle with instruction on use are placed in a pile of cardboard.
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